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If you are not looking for the service manual, but need installation instructions, we have several different manuals and instructions so you can choose the right one.Do you know that the factors affecting drug action pdf can show you new sides and features of your product? That you can look at the specifications of two different chainsaws and decide which one to buy? And you can also find troubleshooting tips, fix your coffee maker and make your day a little bit happier. In this lectureLet understand1. Drug Dosage : Standard dose, Regulated dose, Target level dose, Titrated dose2. Fixed dose combination3. Factors modifying dr Drug reactions may occur extracellularly and involve noncellular constituents. • Physical effects, e.g. protective, adsorbent and lubricant properties of agents applied to the skin.. Chemical reactions, e.g. neutralization of gastric HCl by antacids.. Physicochemical mechanisms may alter the biophysical properties of specific fluids, e.g. surfactants, detergents, antifoaming agents. with drug receptors in adequate numbers to trigger a noticeable action. The course of drug action is, therefore, directly correlated with the concentration of the drug in the blood stream, and is dependent upon the ADME processes. • extracellular • first-pass effect • hydrophilic • interstitial • intracellular • lipids • metabolism Factors modifying the drug action. 1. Factors modifying the DRUG action Sarita Sharma Assistant professor Department of pharmacology Mumbai. 2. On administration of a drug ,a predicted response is obtained but some times Variation in response to the same dose of a drug between different patients and even in the same patient on different occasions. Occasionally individuals exhibit unusual response IDIOSYNCRACY. Drug Efficacy/Intrinsic activity: ability to activate or block a receptor: maximum effect a drug can produce regardless of the dose. Drug Potency/Affinity: rate of drug-receptor binding and drug-receptor release: amount of drug needed to produce a particular effect: drug affinity for receptor: See below: the more potent the drug the quicker it FACTORS AFFECTING DRUG ABSORPTION List of content :– I.PHARMACEUTICAL FACTORS A] Chemical factors B] Physicochemical properties of drug substances 1.drug solubility & dissolution rate 2. Particles size & effective surface area 3. Polymorphism & amorphism 4. Solvates & hydrates 5.salt form of drug 6. Ionization state Pathological states Diseases can influence drug disposition – GIT diseases, Liver diseases, Kidney diseases, Congestive heart failure and Thyroid etc. GIT: Coeliac diseases – amoxicillin absorption decreased while Cephalexin and cotrimoxazole increased; Achlorohydria – Reduced aspirin absorption – NSAIDs aggravate peptic ulcer Liver diseases: Liver disease (cirrhosis) influence drug action Increased bioavailability of drugs with high first pass metabolism Serum albumin reduced Factors that affect drug dissolution of a solid oral dosage form include (1) the physical and chemical nature of the active . drug substance, (2) the nature of the excipients, (3) the method of manufacture, and (4) the dissolution test conditions. + + | This variance of drug action may be due to a number of factors not inherent in the drug itself. This chapter, therefore, deals with the following factors which modify drug action: (1) route of administration, (2) rate and degree of absorption, (3) rate of elimination, (4) effect of other drugs, (5) tolerance, (6) idiosyncrasy and allergy, (7 FACTORS AFFECTING DISTRIBUTION OF DRUGS. 1. Tissue Permeability of Drugs rapid onset of action than poorly perfused adipose tissue. 3) circulation thereby affecting binding of acidic drugs (NSAIDs to albumin) e) DISEASE STATES:- mechanism involved in alteration of drug distribution in disease states. FACTORS AFFECTING DISTRIBUTION OF DRUGS. 1. Tissue Permeability of Drugs rapid onset of action than poorly perfused adipose tissue. 3) circulation thereby affecting binding of acidic drugs (NSAIDs to albumin) e) DISEASE STATES:- mechanism involved in alteration of drug distribution in disease states. Virginia Commonwealth University A drug is a chemical that affects physiological function in a specific way, generally by binding to particular target proteins such as receptors, ion channels, enzymes and carriers. The action of a drug requires the presence of an adequate concentration of the drug in the fluid bathing the target tissue, and this, in turn, is determined by the